A. Yes, you can write off many out of pocket expenses if you itemize deductions, but it's best to keep detailed records.
For example, you can deduct 14 cents per mile for driving in 2016. You can deduct travel related expenses for trips that involve work for a qualified charity.
You must get an acknowledgement from the charity for expenses you cover of $250 or more.
See IRS publication 526, Charitable Contributions, for more details.